Knee Surgery vs. Stem Cells
Rotator Cuff Targeted Stem Cells
How to Avoid Meniscus Surgery
Dr. Baumgartner was the first Minnesota physician to bring stem cell treatments to the upper midwest, by partnering with Regenexx® five years ago. Dr. Baumgartner saw the promising effects of what a patient's own stem cells could do to promote healing and repair and decided to offer this non-invassive procedure.
Regenexx® Stem Cell Treatments: Unlike a standard stem cell procedure, Rejuv Medical has learned to take this procedure a step further and has launched a version of advanced stem cell and platelet procedures from Regenexx®. Though these procedures can not guarantee results for all, there have been many studies done that are proving the results are effective and worthy of practicing. Rejuv Medical continues to strive in pioneering the field of Regenerative Medicine.
Before we can understand how stem cells work, we need to understand how the healing process happens in our bodies and what platelets and stem cells are responsible for in our bodies.
Stem cells are your bodies natural healing cells that are acting daily to make minor repairs to your joints, ligaments, tendons and other tissue. Sometimes the repair process gets overwhelmed by the degenerative process and breakdown and aging/arthritis develops in the joint. By harvesting your bodies own stem cells and concentrating them we can reverse the degenerating process and actually heal degenerating joints and tissue. At Rejuv Medical we do not use a commercial bedside, one size fits all centrifuge machine. We harvest the stem cells from your own bone marrow and then carefully separate the layers of cells in a sterile hood so we can get the purest and highest concentration of cells to treat your specific condition. To augment the healing process for maximal healing, we mix the stem cells with long acting platelets, platelet lysate, and immediate growth factors. Our treatments are tailored to your injury and personal needs. We also look at the nerves surrounding the joint that can impair a regenerative process as well as maximize healing with a functional medicine evaluation prior to any treatment. We know that it is not just injecting cells, but also maximizing and enhancing your bodies response to the treatment.
A STEM CELL is a cell formed in bone marrow created with the purpose to heal and repair areas in our body. PLATELETS also aid in this process by initiating the repair process and signaling repair cells like STEM CELLS to attach to the degenerated or injured tissue to bind and repair.
The healing process involves a complex intercommunication between a wide variety of cells in our body. Routinely the healing cascade happens in three stages: Inflammation, Proliferation, and Remodeling. The irony behind an injury is that many healthcare professionals look at inflammation as a negative response from the body that must be stopped. Ibuprofen is often recommended to slow down the inflammation. Studies confirm that anti-inflammatory medications slow down the healing process and impair healing. Controlled inflammation is actually needed to augment the natural repair and healing process in our bodies. Imagine there were three gears to power your healing response. Each gear is dependent on the process that precedes it. Healing needs Inflammation to start the repair process, followed by Proliferation to grow new healthy tissue and Remodeling to strengthen and mature the injured and degenerated area.
It is an exciting time in orthopedics as we no longer need to rely on surgery or pain medications to treat injuries, pain and arthritis. In fact recent studies looking at knee scope “clean out” surgeries and knee meniscal surgeries actually show no better outcome then exercise alone and after surgery the risk of developing arthritis in that joint actually increases. We now have the technology and research to support the use of STEM CELLS and PLATELETS to reverse joint degeneration from arthritis to ligament and meniscal tearing. Click here to show a list of conditions treated with Regenerative procedures.
1. Growth factors released from activated platelets bind to cell membrane to activate genes controlling mitosis. Notice the different codes of receptors along the membrane of the cell. The platelets match the receptors to signal the appropriate regeneration or transformation process to the Stem Cell.
2. Before signaling here is a growth factor from a platelet.
3. Notice the small size of the Receptor Tyrosine Kinases before activation occurs.
4. Growth Factor binds to the receptors
5. Activation happens in the Receptor Tyrosine Kinases. Notice how it is enlarged.
6. The scaffolding is built and the signal pathway is switched on and the receptor activates the secondary messenger proteins.
7. Secondary messenger proteins now have the power to enter the nucleus to affect expression of genes.
8. This expression of genes is what triggers the appropriate cell division.
When an injury occurs the body sends a healing response and increases blood flow. Platelets are present and begin to repair the damaged tissues. (Figure 1) But notice what happens in figure 2. When we apply PRP or Platelet Rich growth factors to the damaged tissue we have a better cell scaffold for tissue regeneration and repair by reducing the red blood cell pollution. We can even take it a step further and add Stem Cells to increase the cell remodeling, as you will see in diagram 3. The environment in diagram 3 is significantly more conducive to tissue repair than shown in diagram 1.
There are different types of stem cells in our bodies. There are Hematopoietic Stem Cells (HSCs) which turn into new blood cells, but can also help establish much needed blood supply to the healing cascade. In the HSC family there are Pluripotential Hematopietic Stem Cells, Myeloid Stem Cells, and Lymphoid Stem Cells. Because these cells can be found in your blood, some physicians who practice Platelet Rich Plasma Injections (PRP) will refer to PRP as Stem Cell PRP or Advanced PRP. However, blood based stem cells HSCs only increase blood flow and respond very differently than Mesenchymal Stem Cells (MSCs). Mesenchymal Stem Cells can be harvested from adipose / fat tissue on the body, or from the bone marrow of the hip. Research has very little data to show the effectiveness of the fat derived stem cells, whereas the research is strong when studies were performed using bone marrow harvested mesenchymal stem cells. This is why Rejuv Medical uses the MSCs derived from bone marrow in all stem cell based regenerative procedures.
No. This is where an experienced and well a trained physician comes into the picture. platelets and stem cells exist in two states: a resting state and an active state. The cells simply exist in our body in the resting state until called upon by the body to move into the active state. The cells need to be delivered using guidance to the joint and supporting tissues around the joint to achieve maximum healing. Simply injecting dormant cells into the body may not be enough to achieve the desired results. A trained physician, such as those here at Rejuv Medical, use a patented technique that encourages these cells to activate and presume the pseudopod formation (active state) in or around the damaged tissue. By injecting not only the joint but the damaged and weak tissues surrounding the joint, Rejuv’s results are life changing and can be heard and seen in the video testimonies of our patients or the written success stories of our patients.
No. As we covered above, there are many types of adult stem cells. The cells used in these procedures are autologous cells, meaning our body's own cells. These cells have no controversy surrounding them. These cells are not artificially grown or manipulated in a lab and are not embryonic cells taken from embryos.
Yes. There are several studies that have been done supporting stem cell regenerative medicine. Keep in mind, these studies were done using the stem cells harvested from bone marrow. There is not a significant amount of research that has been done using stem cells derived from fat. We have organized the research for you here. Rejuv Medical is an evidence-based clinic. Everything we do has data to support it.
Both Joel Baumgartner, MD and Sidney Kass, MD are trained to perform this procedure.
Yes, when appropriately diagnosed and treated, many patients are having great results with stem cell therapies.
Regenexx® was proud to announce their appearance on “The Doctors” TV show Jan. 25, 2012. The show featured Dr. Centeno and Dr. Hanson in the clinic and lab, as well as Dr. Hanson in their LA studio with patient Barbee James, their patient who required stem cell treatment after a failed micro fracture and continued problems following traditional knee surgery.
Click Here To Watch
The information on this site is solely for purposes of general patient education, and may not be relied upon as a substitute for professional medical care. Consult your own physician for evaluation and treatment of your specific condition.
Rejuv Medical Clinic is in close proximity to Central Minnesota's surrounding cities that include Saint Cloud, Sartell, Waite Park, Sauk Rapids, Rice, Saint Augusta, Luxemburg, Clearwater, Clear Lake, Becker, Big Lake, Elk River, Monticello, Buffalo, Annandale, Kimball, Hutchinson, Rockville, Cold Spring, Richmond, Saint Joseph, Avon, Albany, Melrose, Foley, Milaca, Princeton, Pierz, Little Falls, and Brainerd.
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